The short answer is: probably more than the official recommendation, but less than the mega-doses some corners of the internet suggest.
The RDA for vitamin D is 600 IU per day for adults up to age 70 and 800 IU for adults over 70. These numbers were set by the Institute of Medicine (now the National Academies) in 2011. The Endocrine Society, on the other hand, has suggested that many adults need 1,500-2,000 IU daily to maintain blood levels above 30 ng/mL. Many physicians routinely recommend 1,000-4,000 IU.
Why the disagreement? It comes down to what you think vitamin D should do and what blood level you're targeting.
When your doctor tests vitamin D, they're measuring 25-hydroxyvitamin D, written as 25(OH)D. This is the storage form. Here's how the numbers break down:
| Blood Level (ng/mL) | Status | Notes |
|---|---|---|
| Below 12 | Severely deficient | Risk of rickets (children), osteomalacia (adults) |
| 12-20 | Deficient | Impaired bone health, muscle weakness |
| 20-29 | Insufficient | May not be optimal for overall health |
| 30-50 | Sufficient/Optimal | Target range per most medical organizations |
| 50-100 | No proven extra benefit | Generally safe, but unnecessary |
| Above 100 | Potentially toxic | Risk of hypercalcemia |
The IOM set "sufficient" at 20 ng/mL, primarily for bone health. The Endocrine Society argues that 30 ng/mL is a better target for broader health outcomes. This single threshold disagreement is why you'll see different dose recommendations depending on the source.
An estimated 42% of US adults have 25(OH)D levels below 20 ng/mL. That number jumps to 82% in Black Americans and 69% in Hispanic Americans, largely due to differences in melanin (which reduces vitamin D synthesis from sunlight).
Vitamin D comes in two supplemental forms:
They're not interchangeable. A 2012 meta-analysis in the American Journal of Clinical Nutrition found that D3 is significantly more effective at raising and sustaining 25(OH)D levels than D2. At equivalent doses, D3 was roughly 87% more potent in raising serum levels. D3 also has a longer half-life in the body.
Unless you're vegan (some D3 comes from lichen-based sources now), always choose D3. If your doctor prescribes high-dose D2 (like 50,000 IU weekly), ask about D3 alternatives. Many pharmacies now stock D3 in high-dose capsules.
Forget the official recommendations for a moment. In practice, here's what it takes to reach a blood level of 30+ ng/mL for most adults:
| Scenario | Suggested Daily D3 |
|---|---|
| Currently deficient (below 20 ng/mL) | 4,000-5,000 IU for 8-12 weeks, then retest |
| Insufficient (20-29 ng/mL) | 2,000-4,000 IU for 8 weeks, then retest |
| Maintenance (already 30+ ng/mL) | 1,000-2,000 IU daily |
| Obese individuals (BMI 30+) | May need 2-3x normal doses (D is fat-soluble and sequestered in fat tissue) |
| Malabsorption conditions | Higher doses; work with doctor |
These aren't pulled from nowhere. The Endocrine Society's 2011 clinical practice guideline recommends 1,500-2,000 IU/day for adults at risk of deficiency, and suggests that obese individuals may need 2-3 times more to achieve the same blood levels. A 2014 meta-regression analysis in Nutrients found that each additional 1,000 IU of D3 raises 25(OH)D by approximately 10 ng/mL in adults, though this varies by baseline levels and body weight.
Some groups are far more likely to be deficient and benefit from testing:
If you tick two or more of these boxes, a blood test is worth getting. It's a cheap test—typically $20-50 with insurance—and it removes all guesswork.
Vitamin D is fat-soluble. This has a direct practical implication: taking it with a meal that contains fat significantly increases absorption.
A 2015 study in the Journal of the Academy of Nutrition and Dietetics found that taking vitamin D with a fat-containing meal increased absorption by approximately 50% compared to taking it on an empty stomach. The fat doesn't need to be a lot—even 11g (roughly a tablespoon of olive oil or a handful of nuts) made a significant difference.
Take your vitamin D with breakfast or lunch if those meals contain some fat. Taking it with dinner works too, though some people report it interferes with sleep (this is anecdotal, not well-studied).
You've probably seen "D3 + K2" supplements and wondered if the K2 is necessary.
The theory: vitamin D increases calcium absorption. Vitamin K2 directs that calcium into bones rather than letting it deposit in arteries. Without K2, the extra calcium from D supplementation could theoretically contribute to arterial calcification.
The evidence is mixed. A 2017 review in the International Journal of Endocrinology found that the combination may be more effective for bone health than either alone, but the data on cardiovascular protection is still inconclusive. The Rotterdam Study did find that higher K2 intake was associated with reduced coronary calcification, but this was observational, not a controlled trial of supplements.
Our take: if you're taking moderate doses of D3 (1,000-4,000 IU), K2 supplementation isn't strictly necessary if you eat fermented foods, cheese, or eggs regularly (natural K2 sources). At higher doses or if your diet is low in K2, adding 100-200mcg of MK-7 (the most bioavailable form of K2) is a reasonable precaution. It's very safe and inexpensive.
Vitamin D toxicity (hypervitaminosis D) is real but rare. It almost always involves either accidental mega-dosing or prolonged intake well above 10,000 IU/day.
The mechanism: too much D leads to hypercalcemia (excess calcium in the blood), which can cause nausea, vomiting, muscle weakness, kidney stones, and in severe cases, kidney failure and cardiac arrhythmias.
The IOM set the tolerable upper intake level (UL) at 4,000 IU/day for adults. This is a conservative number with a built-in safety margin. Studies have shown that up to 10,000 IU/day for 5 months doesn't cause toxicity in most healthy adults, but there's no good reason to take that much unless your doctor prescribes it for severe deficiency.
Blood levels associated with toxicity typically start above 100 ng/mL (some cases reported above 150 ng/mL). If you're taking 1,000-4,000 IU daily, you're extremely unlikely to reach these levels.
One notable case series involved patients who took manufacturing-error supplements containing 50,000+ IU per pill instead of the labeled 1,000 IU. Quality control matters. Buy from reputable brands that do third-party testing.
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