Check Your Stack for Conflicts
Add your supplements and medications. See interaction risks instantly. Free on iOS.
Download Free on iOSSuppi's interaction checker scans your entire supplement stack and medications for dangerous combinations, absorption conflicts, and dose overlaps — powered by 500+ peer-reviewed clinical studies from PubMed and Mayo Clinic.
A supplement interaction checker flags dangerous combinations between your supplements and medications before they cause harm. Suppi checks supplement-supplement interactions, supplement-drug interactions, and dose conflicts across your entire stack. The FDA receives tens of thousands of adverse event reports tied to supplements annually, and many involve interactions that a simple check could have caught.
The average supplement user in the US takes four or more supplements daily. Every product you add to your routine increases the chance of an interaction. Some are minor — reduced absorption, digestive upset. Others are genuinely dangerous.
The FDA receives over 50,000 adverse event reports related to dietary supplements each year. Emergency departments see roughly 23,000 supplement-related visits annually. Many of these involve interactions that could have been caught with a simple check before combining products.
The problem is that supplement labels don't warn you about most interactions. They'll mention "consult your doctor" in tiny print, but they won't tell you that your St. John's Wort is making your birth control less effective, or that your calcium supplement is blocking the absorption of your thyroid medication.
Most people don't check. And most doctors don't ask about supplement use during routine visits. That's the gap an interaction checker fills.
Suppi's interaction checker looks at three distinct types of conflicts. Most tools only catch one of these. Suppi catches all three.
Some supplements interfere with each other's absorption or amplify side effects. Calcium blocks iron uptake. Zinc competes with copper. High-dose vitamin C can degrade B12. These conflicts are common and rarely flagged elsewhere.
This is the most dangerous category. St. John's Wort interacts with over 600 medications. Fish oil and vitamin E increase bleeding risk with blood thinners. Grapefruit extract interferes with statin metabolism. Suppi checks your stack against common prescriptions.
Taking a multivitamin plus a standalone vitamin D? You might be hitting 8,000 IU daily without realizing it. Suppi totals overlapping ingredients across all your products and warns you when cumulative doses exceed safe limits.
Suppi's interaction data comes from peer-reviewed clinical research, not crowdsourced opinions. The database draws from 500+ studies indexed on PubMed, interaction data from the Mayo Clinic, safety alerts from the FDA, and ingredient profiles from the NIH Office of Dietary Supplements.
When you add products to your stack in the app, the checker automatically cross-references every ingredient against every other ingredient in your profile. It also checks against any medications you've listed. The analysis runs in real time — add a new product, and you'll see interaction flags within seconds.
The database is updated continuously as new research is published. Supplement-drug interaction data changes as new studies identify previously unknown conflicts. Suppi tracks these updates so your interaction checks always reflect current evidence.
These are real interactions that show up regularly in Suppi's flagging system. Most users had no idea about them before scanning.
Both increase serotonin levels. Combining them can cause serotonin syndrome: rapid heart rate, high blood pressure, agitation, and in severe cases, seizures. This interaction is well-documented but many people take St. John's Wort without telling their doctor.
Fish oil has mild blood-thinning properties. Combined with prescription anticoagulants or even daily aspirin, it can increase bleeding risk during surgery or injury. The effect compounds with high doses of omega-3s.
Calcium binds to levothyroxine in the gut and dramatically reduces its absorption. Patients who take both need to separate them by at least 4 hours. Many people take their thyroid pill and calcium supplement at breakfast without realizing the conflict.
Vitamin K directly counteracts warfarin's mechanism of action. Even moderate supplementation can make the medication less effective, increasing clotting risk. This includes vitamin K found in multivitamins, which people often overlook.
Not dangerous, but wasteful. Calcium significantly reduces iron absorption when taken together. If you supplement both, taking them at different times of day solves the problem completely.
Pharmacists are knowledgeable, but they have limitations when it comes to supplement interactions specifically. Here's how Suppi fits in.
| Factor | Suppi Interaction Checker | Pharmacist | Google Search |
|---|---|---|---|
| Availability | 24/7, instant | Pharmacy hours | Anytime |
| Supplement-Supplement | ✓ Comprehensive | Limited training | Inconsistent |
| Supplement-Drug | ✓ | ✓ Strong | Variable quality |
| Dose Conflict Detection | ✓ Automated | If you bring all bottles | ✗ |
| Knows Your Full Stack | ✓ Saved in profile | Only what you tell them | ✗ |
| Real-Time Updates | ✓ As products change | Periodic training | Outdated articles |
| Clinical Sources | 500+ peer-reviewed | Professional databases | Mixed quality |
| Best For | Ongoing monitoring | Prescription conflicts | Initial awareness |
The ideal approach: use Suppi for continuous, automated monitoring of your entire stack, and consult a pharmacist or doctor for complex prescription interactions or specific medical conditions. They complement each other well.
Add your supplements and medications. See interaction risks instantly. Free on iOS.
Download Free on iOS